Set in Los Angeles, Melinda is primarily about Frankie J. Parker (Calvin Lockhart), a handsome, charismatic and popular disc jockey. A confirmed bachelor and karate enthusiast, he is active in the Black community, even taking lessons at the local dojo of his good friend, Charles Atkins (Jim Kelly).
One evening, he visits the nightclub of his friend, Tank Robertson (Rockne Tarkington), a former professional football player. While there, he meets and becomes enchanted with Melinda (Vonetta McGee), a mysterious woman. Though he dates Terry Davis (Rosalind Cash), a woman who wants to be in a committed relationship with him, he instantly falls for Melinda. Soon after meeting him, she informs him that she sees beyond his playboy façade and appreciates the true essence of him. Her belief in him further endears her to him and he develops serious feelings for her.