Vampire in Brooklyn opens with a mysterious ship crashing into a dockyard in the Brooklyn borough of New York City. The inspector, Silas Green (John Witherspoon), heads aboard, only to discover it is full of mutilated bodies and is almost attacked by a wolf.
His shady and weak nephew, Julius Jones (Kadeem Hardison), arrives afterward to find his frightened uncle and members of the NYPD on the docks. Julius is also shaken because a vampire, Maximillian (Eddie Murphy), just slaughtered local Italian thugs who were threatening Julius. Being famished, he bites Julius, turning him into a ghoul who is to serve Maximillian.