Black Dynamite is set in the South Central community of Los Angeles, California. It is centered upon its main character, Black Dynamite, a man of the streets and questionable means of earning a living. A veteran of the Vietnam War and former operative with the Central Intelligence Agency (CIA), he learns that his younger brother, Jimmy, is murdered. However, his death appears to be more complicated.
Because the CIA knows the character of Black Dynamite, who wants the truth and vengeance, they re-instate Black Dynamite in order to stave off his potential destruction. His investigation leads to his discovery of complicated, nefarious plotting on the Black community, which he has vowed to protect. Integral to this plot is a new drug which is devastating.